However, these compositions fail to maintain effective levels and type of enhancers for bioacceptable absorption enhancement.Method of treating bladder dysfunction with once-a-day trospium salt formulation US7763635 Aug 17, 2007 Jul 27, 2010 Supermus Pharmaceuticals, Inc.Likewise, various embodiments of the invention include a lipophilic component, which can be a lipophilic surfactant, including a mixture of lipophilic surfactants, a triglyceride, or a mixture thereof.Compositions for treating insomnia US8268349 Apr 18, 2012 Sep 18, 2012 Abbott Laboratories Solid pharmaceutical dosage form US8268806 Aug 7, 2008 Sep 18, 2012 Endorecherche, Inc.Preferred solubilizers include triacetin, triethylcitrate, ethyl oleate, ethyl caprylate, dimethylacetamide, N-methylpyrrolidone, N-hydroxyethylpyrrolidone, polyvinylpyrrolidone, hydroxypropylmethyl cellulose, hydroxypropyl cyclodextrins, ethanol, polyethylene glycol 200-600, glycofurol, transcutol, propylene glycol, and dimethyl isosorbide.
Polyethylene glycol is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.Methods and compositions for self-regulated release of active pharmaceutical ingredient US9326958 Oct 21, 2014 May 3, 2016 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases US9333204 Apr 2, 2015 May 10, 2016 Abbvie Inc.The patient can be an animal, preferably a mammal, and more preferably a human.Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants US9480690 Nov 25, 2015 Nov 1, 2016 Lipocine Inc.Keeping these inherent difficulties in mind, and using HLB values as a guide, one skilled in the art can readily identify surfactants having suitable hydrophilicity or lipophilicity for use in the present invention, as described herein.Provide a method of standardization 2. A common size balance sheet expresses each item on the balance.Hydrolyzed lecithin product to improve digestibility US8613918 May 25, 2012 Dec 24, 2013 Curemark Llc Method for treating pervasive development disorders US8613946 Dec 21, 2007 Dec 24, 2013 Isp Investment Inc.The HLB values given in the Tables below generally represent the HLB value as reported by the manufacturer of the corresponding commercial product.
A balance sheet can be analyzed in a number of ways to help investors, bankers and managers understand the true value of a business.Compositions of quaternary ammonium compounds containing bioavailability enhancers US8716262 Dec 23, 2009 May 6, 2014 Gilead Pharmasset Llc Nucleoside phosphoramidates US8716263 Dec 23, 2009 May 6, 2014 Gilead Pharmasset Llc Synthesis of purine nucleosides US8722085 Jul 16, 2010 May 13, 2014 Orexigen Therapeutics, Inc.
Vaginal inserted estradiol pharmaceutical compositions and methods US9301920 Mar 15, 2013 Apr 5, 2016 Therapeuticsmd, Inc.This method is particularly suitable for compositions containing lipophilic actives or additives that result in lipophilic cores.It should be appreciated that there is considerable overlap between the above-listed additives in common usage, since a given additive is often classified differently by different practitioners in the field, or is commonly used for any of several different functions.It should be emphasized that the substrate need not be a solid material, although often it will be a solid.
The described embodiments are to be considered in all respects only as illustrative and not restrictive.Surfactants can be any surfactant suitable for use in pharmaceutical compositions.The spraying solution was prepared by dispersing 15 g of Eudragit L100 in 200 mL of ethanol to give a clear solution.The pharmaceutical compositions of the present invention can optionally include one or more solubilizers, i.e., additives to increase the solubility of the pharmaceutical active ingredient or other composition components in the solid carrier.The sources for these ratios are the coefficients of a balanced equation.Application of HLB to Selected Castor, Hear and Soybean Ethoxylates.The dried, coated beads of Example 3 were further seal coated by a polymer layer.
Solid carriers, typically of size less than about 2 mm, can easily pass through the stomach, thus making the performance less prone to gastric emptying variability.Since the active ingredient is encapsulated in a lipid coat, it will not instantaneously dissolve in the mouth, but will instead dissolve in a region past the oral cavity, thereby substantially avoiding or at least reducing undesirable contact between the active ingredient and the mouth.The enteric coated oral dosage form may also be a capsule (coated or uncoated) containing pellets, beads or granules of the solid carrier or the composition, which are themselves coated or uncoated.Pharmaceutical semi-solid composition of isotretinoin US9084784 Jan 6, 2010 Jul 21, 2015 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces US9089534 Dec 13, 2012 Jul 28, 2015 Galephar Pharmaceutical Research, Inc.Learn more about the drugs you are taking during your cancer or blood disease treatments.
These forms are well known in the art and are packaged appropriately.Particularly preferred solubilizers include sorbitol, glycerol, triacetin, ethyl alcohol, PEG-400, glycofurol and propylene glycol.
Natural combination hormone replacement formulations and therapies US8987238 Dec 6, 2013 Mar 24, 2015 Therapeuticsmd, Inc.A further advantage believed to accrue from the pharmaceutical compositions of the present invention is that upon administration of the composition to a patient, the high levels of surfactants and other components present in the composition facilitate the rapid solubilization of the pharmaceutical active ingredient.Proper atomization and a controlled cooling rate are critical to obtain high surface area, uniform and homogeneous congealed pellets.It is another object of the invention to provide solid pharmaceutical compositions having more rapid dissolution upon administration to a patient.This medication should not be used if you have certain medical conditions.
Nucleoside phosphoramidates WO2011123668A2 Mar 31, 2011 Oct 6, 2011 Pharmasset, Inc.Further, the copolymer is known to be insoluble in gastrointestinal fluids having pH below 5.5, generally 1.5-5.5, i.e., the pH generally present in the fluid of the upper gastrointestinal tract, but readily soluble or partially soluble at pH above 5.5, i.e., the pH generally present in the fluid of lower gastrointestinal tract.In another aspect, the present invention provides a method including the steps of providing a dosage form of a pharmaceutical composition as described above, providing a dosage form of a pharmaceutical active ingredient, and administering the dosage forms to the patient.Soluble estradiol capsule for vaginal insertion US9186330 Jun 30, 2014 Nov 17, 2015 Endo Pharmaceuticals Inc.Pelletizers can be classified based on the angle of their axis as horizontal drum or inclined dish pelletizers.More specifically, suitable unionized ionizable surfactants include the free fatty acid and bile acid forms of any of the fatty acid salts and bile salts shown in Table 18.For hydrophilic active ingredients, the formulation challenges are different.Your universally applicable Polymer CLARIANT TRADE NAMES. with water in any ratio.The HPMC solution was sprayed on the beads as described in Example 6, and the protective coated beads were then dried and collected.
Extended release and targeted delayed release coatings for dosage forms of the compositions of the present invention are described more completely in U.S. Pat. Nos. 5,622,721 and 5,686,105, the disclosures of which are incorporated herein by reference in their entirety.Reason for taking Attention Deficit Disorder with Hyperactivity.Patent US6923988 - Solid carriers for improved delivery of active ingredients in pharmaceutical compositions Advanced Patent Search Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Several methods of atomization of molten mass can be employed, such as pressure, or pneumatic or centrifugal atomization.Refrigerating the mixture before drinking may improve the taste.Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use US8361488 Apr 25, 2008 Jan 29, 2013 Cytochroma Inc.
Shellac, also called purified lac, a refined product obtained from the resinous secretion of an insect.It was a housing boom that allowed the aggregate debt-to-income ratio to reach a record high of close to 170%.Analysis of DEHYDRATION as a potential adverse side effect of MACROGOL.Several commercial products of these hydrophobic drugs are available, the various products using different methods to try to enhance in vivo performance.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.